Conditions · Alzheimer's disease & early-stage dementia
Alzheimer's disease & early-stage dementia — frontier options in Massachusetts
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30 open options
- TRIALPHASE3RECRUITING
Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)
KarXT — 429 sites
- TRIALPHASE3RECRUITING
Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
Acoramidis · Placebo oral tablet — 104 sites
- TRIALPHASE2RECRUITING
A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)
Donanemab · Placebo — 72 sites
- TRIALPHASE2RECRUITING
Assessment of Foralumab Safety and Modulation of Microglial Activation in Alzheimer's Disease
Foralumab TZLS-401 50 µg · Foralumab TZLS-401 100 µg — 1 site
- TRIALNARECRUITING
Mindfulness for Cognition in Early-stage Alzheimer's Disease
Mindfulness Intervention · Waitlist then mindfulness — 1 site
- TRIALPHASE2RECRUITING
A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease
VHB937 · VHB937 · Placebo — 74 sites
- TRIALNARECRUITING
Improving Memory in Alzheimer's Disease With Noninvasive Brain Stimulation
High definition transcranial electrical current stimulation — 1 site
- TRIALPHASE3RECRUITING
A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT).
Donanemab · Placebo — 59 sites
- TRIALPHASE2RECRUITING
Biomarker-based Trial of NPC-1 for Alzheimer's Pathology
natural product combination-1 (NPC1) — 1 site
- TRIALPHASE3RECRUITING
A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease
KarXT · KarX-EC · Placebo — 119 sites
- TRIALPHASE2RECRUITING
A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)
MK-2214 · Placebo — 80 sites
- TRIALNANOT_YET_RECRUITING
The Care for America's Aging Study
Enhanced home health aide training in dementia and dementia-related behaviors — 1 site
- TRIALNARECRUITING
The BRAIN App (Phase 2 SBIR)
The BRAIN App — 1 site
- TRIALNARECRUITING
Treating Insomnia in Mild Cognitive Impairment
Transcranial Magnetic Stimulation (TMS) therapy · Cognitive behavioral therapy for insomnia (CBT-I) — 1 site
- TRIALPHASE3RECRUITING
A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)
KarXT · Placebo — 296 sites
- TRIALPHASE1NOT_YET_RECRUITING
Repurposing a Combination Antiretroviral Drug Therapy to Target Retrotransposons and Treat Early Alzheimer's Disease
Emtricitabine and tenofovir disoproxil fumarate combination · Placebo — 1 site
- TRIALNARECRUITING
Use of a Mobile Brain-Body Imaging Approach to Evaluate the Effects of Rhythmic Auditory Stimulation on Gait and Brain Function in Alzheimer's Disease
Metronome — 1 site
- TRIALNARECRUITING
Non-invasive Brain Stimulation for Cognitive and Motor Dysfunction in Dementia
Transcranial alternating current stimulation (tACS) (active); Transcranial direct current stimulation (tDCS) (active) · Transcranial alternating current stimulation (tACS) (sham); Transcranial direct current stimulation (tDCS) (sham) · Transcranial alternating current stimulation (tACS) (active); Transcranial direct current stimulation (tDCS) (sham) — 1 site
- TRIALPHASE3RECRUITING
Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies
No Intervention — 229 sites
- TRIALPHASE1 / PHASE2RECRUITING
PET Brain Imaging in Multiple Sclerosis, Alzheimer's Disease, and Other Neurological and Neuropsychiatric Diseases
[F-18]PBR06 · [C-11]PBR28 — 1 site
- TRIALPHASE2RECRUITING
Brain Effects of Gamma Frequency Sensory Stimulation (40Hz Light, Sound and Other Devices)
GENUS · Tactile GENUS — 1 site
- TRIALNARECRUITING
Making Connections Thru Music
Volunteer Led Making Connections Thru Music · Staff Led Making Connections Thru Music — 2 sites
- TRIALNANOT_YET_RECRUITING
AI-CONECT: A Conversational AI for Early Dementia Prevention in Socially-Isolated Older Adults
AI-based conversational intervention — 1 site
- TRIALNARECRUITING
Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease
tACS device — 1 site
- TRIALNARECRUITING
Trial to Reduce Antimicrobial Use in Nursing Home Residents With Alzheimer's Disease and Other Dementias 2.0
TRAIN AD 2.0 — 1 site
- TRIALPHASE2RECRUITING
Dexmedetomidine Transdermal Systems (DMTS) Treatment for Agitation Associated With Dementia of the Alzheimer's Type
12 cm2 - 2 Active DMTS Patches · 6 cm2 - 1 Active and 1 Placebo DMTS Patches · Placebo - 2 Placebo DMTS Patches — 9 sites
- TRIALPHASE3RECRUITING
[18F]PI-2620 Phase 3 Histopathological Study
[18F]PI-2620 — 25 sites
- TRIALPHASE2RECRUITING
Study of LHP588 in Subjects With P. Gingivalis-Positive Alzheimer's Disease
LHP588 · LHP588 · Placebo Drug — 39 sites
- TRIALNARECRUITING
Gamma-Music Based Intervention for Mild Alzheimer's Disease
Gamma-Music Based Intervention — 1 site
- TRIALPHASE2RECRUITING
A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Agitation Associated With Alzheimer's Dementia
ITI-1284 · Placebo — 70 sites
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Not medical advice. Trial0 is a navigation service, not a medical provider. Nothing here is medical advice or a recommendation to pursue any treatment; eligibility matching is informational, based on published registry criteria, and only the trial site or treating clinician can determine actual eligibility. Decisions belong with the patient and their own doctors.