Conditions · Alzheimer's disease & early-stage dementia
Alzheimer's & early-stage dementia frontier treatment options
Anti-amyloid and anti-tau programs, and most disease-modifying trials, publish narrow windows — typically MCI to mild stage with biomarker confirmation. The map shows which published windows a profile plausibly fits.
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Open options now (1154 open studies; showing 30)
- TRIALNARECRUITING
German Validation Study of the Subjective Cognitive Decline Questionnaire (SCD-Q)
Subjective Cognitive Decline-Questionnaire (SCD-Q) · Cognitive Failure Questionnaire (CFQ) · biomarkers — 1 site
- TRIALNARECRUITING
Inspiring Seniors Towards Exercise Promotion to Protect Cognition
Beat-accentuated, personalized music stimulation (BMS) · Strength Training (ST) · Aerobic exercise (AE) — 2 sites
- TRIALNANOT_YET_RECRUITING
Treatment of Periodontal Disease in Patients With Alzheimer's Disease
periodontal therapy
- TRIALPHASE1RECRUITING
BnH-015B Clinical Trial in Moderate Alzheimer's Disease
BnH-015B 5 mg · BnH-015B 10 mg · BnH-015B 20 mg — 1 site
- TRIALPHASE3RECRUITING
Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)
KarXT — 429 sites
- TRIALPHASE3RECRUITING
Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
Acoramidis · Placebo oral tablet — 104 sites
- TRIALNAENROLLING_BY_INVITATION
The Role of Advanced Electroencephalographic Data as Marker of Pathology and Prognosis in Primary Dementias
Electroencephalogram · 3 Tesla MRI · Apolipoprotein E genetic test — 1 site
- TRIALPHASE2RECRUITING
Effects of THC-Free CBD Oil on Agitation in Patients With Alzheimer's Disease
THC-free CBD Oil · Placebo — 1 site
- TRIALPHASE2RECRUITING
A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)
Donanemab · Placebo — 72 sites
- TRIALNANOT_YET_RECRUITING
Center for Research and Education on Aging and Technology Enhancement - CREATE V - Project 2
Project 2, Phase 2: Intelligent Adaptive System — 3 sites
- TRIALNANOT_YET_RECRUITING
Transcranial Alternating Current Stimulation for Patients With Mild Alzheimer's Disease II (TRANSFORM-AD II)
sham stimulation · transcranial alternating current stimulation — 1 site
- TRIALNARECRUITING
dTMS for Subjective Cognitive Decline
Active Brainsway H7-Coil Deep TMS System · Sham Brainsway H7-Coil Deep TMS System · Cognitive Training — 1 site
- TRIALNARECRUITING
Virtual Darkness Theraphy for Agitation in Dementia
Virtual darkness — 1 site
- TRIALNANOT_YET_RECRUITING
ALDH2 Genetic Testing in East Asian Community
Genetic Test Results Return · Alcohol Flushing Education — 1 site
- TRIALNARECRUITING
Understanding Brain Mechanisms Involved in Autobiographical Memory
high-density electroencephalography (hdEEG) · Transcranial alternating current stimulation (tACS) — 1 site
- TRIALNARECRUITING
Closed-Loop Brain Stimulation as a Potential Intervention for Cognitive Decline
Closed-loop TBS · Open-loop TBS — 1 site
- TRIALNARECRUITING
Nursing Interventions for Alzheimer's Patients During PET/CT Imaging
Effects on Image Quality and Patient Satisfaction · Anxiety degree of patients after nursing — 1 site
- TRIALNARECRUITING
EfFect of Ablation of Persistent AtriaL Fibrillation on COgNitive Function in Individuals With Mild Cognitive Impairment
Atrial fibrillation ablation + antiarrhythmic drugs · Antiarrhythmic drug — 8 sites
- TRIALPHASE3NOT_YET_RECRUITING
Alzheimer's Disease THErapy With NEuroaid II
MLC 901 · Placebo — 1 site
- TRIALPHASE2NOT_YET_RECRUITING
Neuroplasticity Enhancement From Cognitive Training Reinforced by Psilocybin
Psilocybin · Cognitive Training — 1 site
- TRIALNAENROLLING_BY_INVITATION
Software Validation Study-Cognitive Status Indicator
SPARK Cognitive Status Indicator (software support data collected via EEG) — 1 site
- TRIALNARECRUITING
Feasibility, Usability, and Acceptability of Virtual Reality-Based Cognitive and Physical Rehabilitation in Individuals With Mild Cognitive Impairment
Virtual Reality (VR) sessions — 1 site
- TRIALNARECRUITING
Training App for Inhibitory Control Towards Food
Food-specific inhibitory control training delivered through the FoodTraining App · Waiting list — 1 site
- TRIALNARECRUITING
BID WM Digital Intervention in Aging
Coherence · Worder — 1 site
- TRIALNANOT_YET_RECRUITING
Dyadic Life Review Intervention for Older Patients With Advanced Cancer and Alzheimer's Disease and Related Dementias and Their Caregivers
Dyadic Life Review — 1 site
- TRIALNARECRUITING
Connect-Home: Alzheimer's Disease and Related Dementias
Connect-Home ADRD — 1 site
- TRIALNARECRUITING
Michigan Healthy Mom (MI-MOM) Pregnancy Improvement Web Application Trial
MI MOM App — 8 sites
- TRIALPHASE2RECRUITING
N-AD: Orally Administered Nicotinamide Riboside Over Two Years as a Potential Disease Modifying Treatment for Alzheimer's Disease
Nicotinamide Riboside (NR) · Palacebo — 2 sites
- TRIALPHASE2RECRUITING
Open-label Extension Study in Participants With Early Alzheimer's Disease
GSK4527226 — 33 sites
- TRIALNARECRUITING
Identification of Diagnosis Biomarkers in the Tears of Alzheimer's Disease Patients: The COG-EYE Pilot Study
Basal tear collection for the analysis of metabo-lipidomic profiles and concentrations of protein biomarkers (Tau, phosphorylated Tau, Aβ 1-40, and Aβ 1-42) · Collection of a blood sample (5 mL) for blood biomarkers analysis — 1 site
Live from ClinicalTrials.gov, refreshed at most hourly · registry query ↗
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Each country page filters the live registry to listed sites in that country and links to the relevant official national or regional registry for additional local discovery.
Common questions
- How does Trial0 find Alzheimer's disease & early-stage dementia options?
- Every list on this page is a live query of ClinicalTrials.gov (API v2) for open interventional trials and expanded-access programs, refreshed at most hourly. Nothing is hand-curated or cached beyond that window.
- Does a match mean the patient is eligible?
- No. Structured registry fields (age, sex, status, phase) give firm matched/not-matched states; free-text criteria can only be checked for mentions, which are signposts to verify with the site. Only the trial site can determine actual eligibility.
- What does the verified site data mean?
- Registry recruiting status is often stale. Trial0 separately records first-hand observations — whether a specific site is really recruiting and whether the investigator accepts outside referrals — each stamped with the date it was verified.
- What does access help cost?
- The eligibility map and new-trial alerts are free. Pro is $49/month or £49/month and covers contact research, draft preparation and approval-first outreach. Trial0 never takes a commission from a provider.
How to use this Alzheimer's disease & early-stage dementia trial page
This page is refreshed from live registry data and shows currently open interventional studies and expanded-access programmes. Trial records are leads, not a clinical recommendation.
Use the full matcher to add age, treatment history, biomarkers and a location. It labels published criteria honestly: a mention in free text is a prompt to verify, not a finding of eligibility.
Free alerts help you notice new registry entries. Pro can research a contact and prepare outreach, but Trial0 asks for approval before contacting each trial.
Not medical advice. Trial0 is a navigation service, not a medical provider. Nothing here is medical advice or a recommendation to pursue any treatment; eligibility matching is informational, based on published registry criteria, and only the trial site or treating clinician can determine actual eligibility. Decisions belong with the patient and their own doctors. Data refreshed at most every 1 hour(s).