18F-L-Fluoro-DOPA PET/CT Scan Localization of Focal Pancreatic Lesions in Subjects With Hyperinsulinemic Hypoglycemia

Summary

This purpose of this study is to determine the ability of an 18F-fluoro-L-dihydroxyphenylalanine (18F-DOPA) PET (Positron Emission Tomography) scan to detect a focal lesion of hyperinsulinism and determine the location in patients with congenital hyperinsulinism, Beckwith Wiedemann Syndrome and suspected insulinoma. Safety data will be collected.

Interventions

• 18F-DOPA · DRUG

  18F-DOPA is a PET (Positron Emission Tomography) scan radiotracer.

Published eligibility criteria

Verbatim from the registry. Only the site can decide how these apply to a specific patient.

Inclusion Criteria:

* Subjects of any age with hyperinsulinemic hypoglycemia, diagnosed by a fasting test and/or response to glucagon stimulation.
* Subjects who are eligible for pancreatic surgery regardless of prior pancreatic surgery

Exclusion Criteria:

* Pregnant or lactating females
* Any other major illness or condition that in the investigator's judgment will substantially increase the risk associated with the subject's participation in this study
* Subjects who are not a candidate for pancreatic surgery

Sites (1)

• Children's Hospital of Philadelphia, Philadelphia, Pennsylvania · Available