Obstructive Sleep Apnea and Biomarkers of Alzheimer's Disease

Summary

Clinical trial on the effect of continuous positive pressure (CPAP). Objectives: 1) To compare biomarkers of Alzheimer's disease in plasma samples from patients with Obstructive sleep apnea (OSA) and without OSA. 2) To determine if CPAP reduces biomarkers of Alzheimer's disease in plasma samples.

Interventions

• Continuous positive airway pressure · DEVICE

  Continuous positive airway pressure

Published eligibility criteria

Verbatim from the registry. Only the site can decide how these apply to a specific patient.

Inclusion Criteria:

* Cases: patients with AHI \> 30/h
* Controls: subjects with AHI \< 5/h and Epworth \<10

Exclusion Criteria:

* Epworth\>18
* BMI\<40Kg/M2
* Arterial Hypertension
* Diabetes Mellitus
* Cerebrovascular disease
* Ischemic heart disease
* Cardiac arrhythmia
* Chronic cardiovascular diseases
* Daytime Oxygen saturation\>95%
* Risk professions (professional drivers)
* Concomitant treatment with antihypertensives, statins, antidiabetics, beta- blockers or systemic corticosteroids.
* Pretreatment with CPAP.
* Participation in another clinical trial thirty days prior to randomization
* Abnormal values of a cognitive test.

Sites (2)

• Hospital Son Espases, Palma, Balearic Islands
• Hospital Son Llatzer, Palma, Balearic Islands