Pilot Comparing ctDNA IDV vs. SPV Sample in Pts Undergoing Biopsies for Hepatobiliary and Pancreatic Cancers

Summary

This is a prospective pilot protocol investigating whether ctDNA detection be improved by sampling the cancer draining vein versus the standard practice of sampling from a peripheral vein in patients who are undergoing biopsies for hepatobiliary and pancreatic cancers.

Interventions

• ctDNA Blood Collection · DIAGNOSTIC_TEST

  Blood collection to be obtained from peripheral vein and cancer draining vein during biopsy

Published eligibility criteria

Verbatim from the registry. Only the site can decide how these apply to a specific patient.

Inclusion Criteria:

* 18 years of age or older
* Have or are undergoing work-up for hepatobiliary and/or pancreatic carcinoma (such as hepatocellular carcinoma, cholangiocarcinoma, ampullary carcinoma, pancreatic carcinoma)
* Scheduled for an image-guided percutaneous or trans-jugular biopsy of a lesion
* Must be able to provide a written informed consent

Exclusion Criteria:

* Patients unable to hold reasonably still on a procedure table or hold their breath during imaging or needle passes
* Patients with a gross body weight over 375 pounds (upper limit of the CT and angiography tables)
* Patients with uncorrectable coagulopathy
* Platelet count \< 30,000/ul
* International Normalized (INR) \> 1.5
* Patients with moderate to severe ascites who cannot undergo trans-jugular biopsy or sufficient drainage
* No clear reachable target for percutaneous or trans-jugular biopsy
* Patient who cannot have a peripheral blood draw for ctDNA

Sites (1)

• Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, California · Recruiting