PANCREATIC CANCER: DYNAMIC ASSESSMENT AT ALL STAGES OF TREATMENT

Summary

The study consists of a 25 ml blood sample collection: * Before the start of treatment * Approximately 2 months after the start of induction chemotherapy * At the end of induction chemotherapy * Prior to local treatment (radiotherapy, surgery) * At the time of tumor progression Collection of tumor material: * During the initial diagnostic biopsy * On the operating room in case of surgery * At tumor biopsy in case of recurrence or progression (optional) As well as the completion of a questionnaire at inclusion.

Interventions

• collection of blood and tumor samples · OTHER

  The study consists of the collection of a 25 ml blood sample: * Before the start of treatment * Approximately 2 months after the start of induction chemotherapy * At the end of induction chemotherapy * Prior to local treatment (radiotherapy, surgery) * At the time of tumor progression At the time of collection of tumor material: * During the initial diagnostic biopsy * On the operating room in case of surgery * During a tumor biopsy in case of recurrence or progression (optional) and a questionnaire evaluating the patient's spontaneous physical activities.

Published eligibility criteria

Verbatim from the registry. Only the site can decide how these apply to a specific patient.

Inclusion Criteria:

* Non-metastatic pancreatic adenocarcinoma that is not immediately resectable (borderline and locally advanced tumors according to the NCCN 2020 classification)
* No previous treatment with surgery or chemotherapy
* Age \> 18 years
* General condition WHO 0-2 (patient whose general condition can allow medical treatment or surgery)
* Therapeutic management at the Paoli-Calmettes Institute
* Signature of the informed consent specific to the PANDORE-PANC study
* Patient affiliated to a social security system or benefiting from such a system

Exclusion Criteria:

* Metastatic disease
* Pancreatic tumor of a histological type other than adenocarcinoma
* Other tumor under treatment or for which treatments have been completed for \< 1 year
* Pregnant or breastfeeding women
* Person in an emergency situation
* Person of legal age under legal protection (guardianship, curatorship or safeguard of justice) or unable to give consent.

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