Surveillance of Pancreatic Health After Diabetes Diagnosis

Summary

The goal of this interventional study is to evaluate if the novel diagnostic blood test, called Avantect can early detect pancreatic cancer in patients diagnosed with type 2 diabetes or with elevated sugar levels within the last 200 days. Participants will: * attend 3 study visits over 12 months time * provide a blood sample at each study visit * complete an anxiety questionnaire at each visit.

Interventions

• Avantect Pancreatic Cancer Test · DEVICE

  Avantect test

Published eligibility criteria

Verbatim from the registry. Only the site can decide how these apply to a specific patient.

Inclusion Criteria:

* 50 - 84 years of age at the time of enrolment (within year of birth, not month of birth)
* Confirmed type 2 DM diagnosis established within the last 200 days or an initial elevated HbA1c ≥ 48 mmol/mol or 6.5% obtained within the last 200 days. This includes people who have a first elevated HbA1c (≥ 48 mmol/mol or 6.5%) within the last 200 days, even if subsequent HbAc1 measurements return to the the normal range.
* Willing to provide up to 30 mL of blood for each study visit
* Willing and eligible to undergo MRI or CT scan
* Understands the study process and is willing to take part in the study and sign the informed consent form

Exclusion Criteria:

* Prior type I or type II DM diagnosis or an initial HbA1c ≥ 48 mmol/mol or 6.5% obtained prior to the 200-day inclusion window, except gestational elevated HbA1c.
* A history of pancreatic cancer, pancreatic neuroendocrine tumour (pNET) or Pancreatitis
* Under investigation for or confirmed pancreatic cancer
* Under investigation/surveillance for pancreatic cyst
* Any known pancreatic surgery (not including ERCP), or other major surgery requiring anaesthesia within 3 months
* Any invasive solid or haematological cancer in the past 3 years, including cancer recurrence after treatment in the last 3 years
* BMI \> 40 at the time of consent
* Blood transfusion within 1 month
* Solid organ transplant recipient
* Currently pregnant
* Needing dialysis

Sites (31)

• Ashfields Primary Care Centre, Sandbach, Cheshire · Active, not recruiting
• Maidstone and Tunbridge Wells NHS Trust, Maidstone, Kent · Recruiting
• Forest Medical Group, Leicester, Leicester Forest East · Recruiting
• South Leicestershire Medical Group, Kibworth Beauchamp, Leicestershire · Recruiting
• Peel Croft Surgery, Burton-on-Trent, Staffordshire · Recruiting
• Kingswinford Medical Practice, Kingswinford, Staffordshire · Recruiting
• Park Medical Centre, Leek, Staffordshire · Recruiting
• Trinity Court Surgery, Stratford-upon-Avon, Staffordshire · Recruiting
• Brockwood Medical Practice, Brockham, Surrey · Recruiting
• Integrated Care Partnership/ The Old Cottage Hospital, Epsom, Surrey · Recruiting
• Warlingham Green Medical Practice, Warlingham, Surrey · Recruiting
• Ashton Medical Group, Ashton-under-Lyne, United Kingdom · Active, not recruiting
• Yardley Wood Health Centre, Birmingham, United Kingdom · Recruiting
• Bournemouth Research Hub, Bournemouth, United Kingdom · Active, not recruiting
• Eastham Group Practice, Bromborough, United Kingdom · Recruiting
• Willesden Medical Centre, London, United Kingdom · Recruiting
• South Westminster Centre, London, United Kingdom · Recruiting
• The Cuckoo Lane Practice, London, United Kingdom · Recruiting
• Bodey Medical Centre, Manchester, United Kingdom · Active, not recruiting
• Bowland Medical Practice, Manchester, United Kingdom · Active, not recruiting
• The Maples Medical Centre, Manchester, United Kingdom · Active, not recruiting
• King's Mill Hospital (Sherwood Forest) Research Van, Nottingham, United Kingdom · Recruiting
• Portsmouth Research Hub, Portsmouth, United Kingdom · Active, not recruiting
• Hazelvalley Family Practice, Rossendale, United Kingdom · Recruiting
• Pembroke Centre (Hillingdon), Ruislip, United Kingdom · Recruiting
• Southampton Research Hub (Shirley Research Hub), Southampton, United Kingdom · Active, not recruiting
• Moorgreen Hospital, Southampton, United Kingdom · Recruiting
• Balance Street Health Centre, Uttoxeter, United Kingdom · Recruiting
• Civic Centre, Uxbridge, United Kingdom · Recruiting
• Quinton Practice, Walsall, United Kingdom · Recruiting
• Weymouth Research Hub, Weymouth, United Kingdom · Active, not recruiting