Phase I Trial of pH Resections of GBM at VA

Summary

Glioblastoma is an infiltrating tumor that is difficult to visualize in surgery and on standard images. A special pH (acid-base) related magnetic resonance imaging (MRI) has been developed to better see infiltrating tumor. In this safety study, the investigators will carry out increased levels of pH based resections of infiltrating tumor to assess the tolerability in VA populations.

Interventions

• pH MRI based resection of GBM · PROCEDURE

  This will require a chemical exchange saturation transfer MRI followed by surgical resection based on this MRI.

Published eligibility criteria

Verbatim from the registry. Only the site can decide how these apply to a specific patient.

Inclusion Criteria:

* Ability to provide written informed consent
* Karnofsky Performance Scale (KPS) of 70 or higher
* Suspected, newly diagnosed or recurrent IDH wild type WHO IV glioblastoma presenting as an intra-axial
* Expansile contrast-enhancing mass without evidence of metastatic disease

Exclusion Criteria:

* Diagnostic uncertainty such as history of extracranial malignancy or autoimmune disease
* Medical conditions prohibiting anesthesia or surgery
* Tumors involving eloquent brain areas as defined by MRI signal
* primary motor cortex, primary sensory cortex, sensorimotor fibers, primary language areas, arcuate fasciculus

Sites (1)

• VA Greater Los Angeles Healthcare System, West Los Angeles, CA, West Los Angeles, California