Feasibility, Usability, and Acceptability of Virtual Reality-Based Cognitive and Physical Rehabilitation in Individuals With Mild Cognitive Impairment

Summary

The purpose of this study is to demonstrate feasibility, usability, and acceptability of virtual reality (VR)-based cognitive and physical rehabilitation, evaluate adherence, tolerability, and fidelity to the VR intervention and explore preliminary effectiveness of VR-based rehabilitation on cognitive, physical, and functional outcomes.

Interventions

• Virtual Reality (VR) sessions · DEVICE

  Participants will complete 3 supervised virtual reality (VR) sessions per week for 6 weeks for a total of 18 sessions using either the Real System VR headset or the Oculus Quest 2 VR headset. Each session will last approximately 60 minutes, with time allocated for setup and brief symptom checks.

Published eligibility criteria

Verbatim from the registry. Only the site can decide how these apply to a specific patient.

Inclusion Criteria:

* Clinical diagnosis of MCI (MoCA 18-26) or self-reported subjective cognitive decline (SCD)
* Capacity to provide informed consent
* Able to provide own transportation to sessions
* Speaks and understands English
* Ambulatory

Exclusion Criteria:

* Uncontrolled seizures or epilepsy
* Severe psychiatric illness or active suicidality
* Inability to follow instructions or tolerate VR (severe motion sickness)
* Cognitive impairment as a result of a known cause (e.g., dementia, stroke, Traumatic Brain Injury (TBI), medications, etc.)
* Any condition that the research team determines would interfere with safe participation

Sites (1)

• The University of Texas Health Science Center at Houston, Houston, Texas · Recruiting