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Clinical trial · NCT07817147

CREO - Microwave Ablation Feasibility Study

Recruiting

Sponsor: Banner Health

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Summary

The goal of this study is to assess the overall success of energy delivery during treatment using the ultrasound guided microwave ablation device in patients with locally advanced, unresectable, or metastatic cancer. Secondly, this study aims to explore the procedural/clinical safety of treatment with the device and the antitumor effect following treatment with the device.

Interventions

  • EUS-Guided MWA Device · DEVICE

    The rationale of this study is to generate preliminary data on the functionality and safety of Creo's MicroBlate™ Fine device when used under EUS guidance. The results generated from this study will inform any decisions regarding subsequent pivotal trials and may support the integration of this approach into clinical practice for anatomically challenging tumors.

Published eligibility criteria

Verbatim from the registry. Only the site can decide how these apply to a specific patient.

Inclusion Criteria:

* Male or female ≥18 years of age
* Willing and able to provide written informed consent
* Histologically confirmed locally advanced, unresectable or metastatic cancer (Stage III or IV)
* At least 1 tumor that is indicated for MWA, and the location of target tumor must be accessible via EUS through the gastric wall (eg, pancreas, liver, etc).
* The tumor(s) must be ≥1 cm in diameter

Exclusion Criteria:

* Participant is a candidate for upfront resection of pancreatic cancer
* Participation in another clinical trial that involves local ablation or any other local therapy that could affect the target organ or lesions treated in this study
* Any condition that, in the opinion of the investigator, may increase the risk to the participant's safety or well-being

Sites (7)

  • Banner MD Anderson Cancer Center and Gateway Hospital, Gilbert, Arizona · Recruiting
  • Cedars Sinai, Los Angeles, California · Not yet recruiting
  • Rush University Medical Center, Chicago, Illinois · Not yet recruiting
  • Mayo Clinic Rochester, Rochester, Minnesota · Not yet recruiting
  • University of Tennessee Medical, Knoxville, Tennessee · Not yet recruiting
  • Memorial Hermann-Texas Medical Center, Houston, Texas · Not yet recruiting
  • West Virginia University Medicine, Morgantown, West Virginia · Not yet recruiting

Not medical advice. Trial0 is a navigation service, not a medical provider. Nothing here is medical advice or a recommendation to pursue any treatment; eligibility matching is informational, based on published registry criteria, and only the trial site or treating clinician can determine actual eligibility. Decisions belong with the patient and their own doctors. Registry data refreshed at most hourly; last update posted 2026-09-14.